In Motley Fool article “2 Biotech Stocks That Could Double Your Money“
According to author Zhiyuan Sun, Biotech stocks have been extremely popular among investors in 2020. Over the past year, the iShares NASDAQ Biotechnology ETF(NASDAQ: IBB), an industry indicator, has returned over 33%, compared to the S&P 500’s 14% return during the same period. It’s clear that a lot of eyes are on producers of testing supplies, drugs, and vaccines for the coronavirus leaving other less noticed companies undervalued.
Vertex Pharmaceuticals (NASDAQ: VRTX) has become a leader in the treatment of cystic fibrosis. This hereditary disease severely restricts patients’ ability to breathe due to abnormally viscous fluid accumulating in the lungs. Vertex’s triple-combination cystic fibrosis therapy, Trikafta, improved patients’ respiratory volume by 14.3% compared to placebo in clinical trials.
CRISPR Therapeutics (NASDAQ: CRSP) has already made investors richer with a 235% return over the past year. Right now, it is leveraging its gene-editing technology to help patients overcome hereditary blood disorders such as sickle cell anemia and beta thalassemia. These cause severe, life-threatening deformities in patients’ red blood cells and occur in over 360,000 newborns worldwide each year.
Avalon GloboCare (NASDAQ: AVCO) could be one of the most undervalued Biotech stocks that has disruptive technology in CAR-T immunotherapy that applies to both cancer (specifically leukemia) as well as COVID-19. Avalon uses a proprietary S-Layer “surface layer” technology to develop an intranasal vaccine that attaches to the mucosal membrane CEO Dr. David Jin pointed out. “We see our vaccine candidate as a complement to any injectable vaccines in clinical trials, because it could provide first-line immune protection at the virus’s entrance site”. Adding a coat of an S-layer onto solid surfaces can greatly improve the function of a therapeutic, vaccine, or device. The S-layer allows enhanced efficiency and interaction of targeted proteins and molecules for better function.
Avalon GloboCare is in the process of establishing a state-of-the-art research facility, the Christian Doppler Laboratory, located on the BOKU campus in Vienna, Austria, under the scientific leadership of Professor Eva-Kathrin Ehmoser, the Head of BOKU’s Institute for Synthetic Bioarchitectures and Professor Uwe Sleytr, a member of the Austrian Academy of Sciences. In connection with the new facility, Avalon and BOKU have signed a Memorandum of Understanding (MOU) to jointly apply for a matching research grant from the prestigious Christian Doppler Laboratory Foundation. Avalon also has research being done in MIT (Massachusetts Institute of Technology), the UNRLS (University of Natural Resources and life sciences in Australia), Weill Cornell Medicine in New York City and the Lu Daopei Medical Group in China, which has the country’s top ranked hematology and bone marrow transplant program
In the December 2020 issue of Nature’s Biopharma Dealmakers, Avalon’s President and CEO, David Jin, M.D., Ph.D., highlighted Avalon’s ongoing scientific and clinical developments including a first-in-human trial of a mucosal, intranasal vaccine against SARS-CoV-2 that is planned for early 2021. Dr. Jin also described the company’s innovative, allogeneic mesenchymal stromal cell (MSC) therapy candidate, CB-MSC-1, which possess unique anti-inflammatory and immunomodulatory activities, as well as AVA-001, Avalon’s third-generation CAR T cell therapy that has shown robust activity in patients with relapsed, refractory B cell acute lymphoblastic leukemia in a Phase 1 trial (Avalon feature in Biopharma Dealmakers).
“We are excited and motivated to join forces with the researchers at BOKU to drive innovation. We have already begun a collaboration on the mucosal SARS-CoV-2 vaccine and are moving quickly to establish additional joint research endeavors to bring about innovative technologies and new medicines to patients,” said Dr. Jin.
Avalon GloboCare, is a young, $100 million market cap company that has arguably some of the brightest minds in cell-based technology who have a competitive advantage with their “S-Layer” technology in a vaccine market that is expected to grow to approximately 93.billion by 2026 according to Forbes business . This small cap biotechnology company is working towards the goal of changing the way we fight the devastating affects of diseases that relentlessly attack our immune systems by using our own bodies against us. In the first quarter of 2020, Avalon GloboCare successfully completed a phase 1 first-in-human clinical study of AVA-001 in China for the treatment of relapsed refractory B cell acute lymphoblastic leukemia (R/R B-ALL). 90% of R/R B-ALL patients achieved complete remission with one dose and within one month of treatment, and then proceeded to a curative-intent allogeneic bone marrow transplant. With more upcoming catalysts in Q4 2020 and early 2021, it is safe to say that there is a large potential upside in AVCO’s stock that currently trades at only $1.14. The company has been well capitalized to date and has very clean cap table relative to its industry peers making it an attractive investment.
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