Creative Medical Technology Holdings, Inc. is a clinical-stage biotechnology company focused on treating erectile dysfunction and stroke using stem cell treatments. Since 2011 Creative Medical Technology Holdings, Inc. and our affiliate company Creative Medical Health, Inc. have focused on regenerative medical solutions for unmet Urological and Neurological needs. Through our own research and collaborations with leading academic institutions, CMT has acquired a groundbreaking stem cell (Amniostem), developed proprietary protocols, built an extensive intellectual property portfolio, developed complete treatment offerings for erectile dysfunction, launched a 40-patient trial for ED at UCLA and are breaking new ground for treating stroke using our newly acquired amniotic fluid-based stem cell. Our team consists of leading international researchers in regenerative medicine. Our “science-first” approach to treatments ensures that all of our treatments are proven to be both safe and effective.

 Creative Medical Technology Holdings, Inc. Press Release

PHOENIX, May 8, 2018 /PRNewswire/ — Creative Medical Technology Holdings announced today filing of patent application number 62663912 covering the use of its AmnioStemTM stem cells as a means of reducing/reversing natural aging.

Previous studies by the Company have demonstrated that AmnioStemTM cells secrete factors that are capable of rejuvenating aged cells.  By encapsulating the cells outside of the body, so that the cells are in contact with the patient’s circulation, the cells are permitted to secrete factors that may reduce aging, without having to inject the cells in the patient.

The concept of using cells that are growing outside of the body as a means of modifying physiological activities has previously been performed and appears feasible.  Specifically, similar approaches to mixing patient blood with cells outside of the body have previously been attempted in the area of liver failure.  A clinical trial demonstrated feasibility of using cell culture of hepatocytes to act as a “liver assist device”.  These devices are currently in Phase 3 of clinical trials1,2.

The filed patent describes a similar approach to those used in liver failure, with the exception that instead of using hepatocytes outside of the body, the device uses AmnioStemTM amniotic fluid derived stem cells.

“Previous studies from Stanford University3 and Harvard University4 have shown that if the circulation of an aged mouse is connected to the circulation of a young mouse, various factors secreted by young mice induce an anti-aging/rejuvenating effects on organs/tissues of aged mice.  Through this patent, we are aiming to recapitulate this effect, in an ethical and technically feasible manner.” Said Dr. Thomas Ichim, the Company’s Chief Scientific Officer. “What is stunning about the AmnioStemTM stem cell, which was licensed by the Company from the University of California San Diego, is that it possesses many regenerative features but is collected from non-controversial sources.”

The AmnioStemTM stem cell is derived from amniotic fluid during the process of amniocentesis.  Amniotic fluid is typically considered medical waste.  Scientists at University of California San Diego have developed means of extracting and growing stem cells from the amniotic fluid.  These stem cells have been published to be capable of treating animal models of numerous diseases including stroke5, heart attack6, liver failure7, colitis8, diabetes9, emphysema10, and kidney injury11.  An important activity of amniotic fluid stem cells is that cells derived from one person can be used to treat other people, making them “universal donor” stem cells.

“The concept of using young blood to stimulate regeneration in aged individuals is attracting much attention in the area of regenerative medicine.  I am enthusiastic about the approach being developed by Creative Medical Technology Holdings, which overcomes some of the important roadblocks that prevent implementation of this novel and promising approach,” said Amit Patel, MD, MS, Chief of Cardiothoracic Surgery University of Miami and coinventor of the patent.

“At Creative Medical Technology Holdings we are committed to advancing regenerative medicine to various areas of human suffering.  In contrast to other conditions, aging will occur in everyone,” said Timothy Warbington, President and CEO of Creative Medical Technology Holdings. “While the field of anti-aging medicine is filled with various false hopes and hype, we are attempting to address this problem cautiously and methodologically through testing our technology for safety and efficacy.

“Our goal is to continue to internally develop and patent technology in the regenerative medicine space and to broaden our patent portfolio for future commercialization by the company and/or with other life science companies with complementary technology.”

 About Creative Medical Technology Holdings

Creative Medical Technology Holdings, Inc. is a commercial stage biotechnology company currently trading on the OTCQB under the ticker symbol CELZ. For further information about the company go to www.creativemedicaltechnology.com. 

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