China is starting clinical trials of a Covid vaccine that can be inhaled as Avalon Globocare leads the way

Keep your eye on is Avalon GloboCare (NASDAQ:AVCO)

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According to CNBC article “ China is starting clinical trials of a Covid vaccine that can be inhaled”.

China’s CanSino Biologics will be starting clinical trials for a Covid-19 vaccine that is administered through inhalation next week, the company’s co-founder and Chief Executive Xuefeng Yu told CNBC on Sunday.

Efficacy rates for China’s Covid vaccines have been found to be lower than those developed by Pfizer-BioNTech (NYSE PFE) (NASDAQ:BNTX) and Moderna. (NASDAQ MRNA) Earlier this month, the director of the Chinese Center for Disease Control publicly acknowledged that Chinese vaccines “don’t have very high protection rates” and that they were considering giving people different Covid shots to boost vaccine efficacy.Yu told CNBC that an inhaled vaccine could be more effective than those injected given that the coronavirus enters the human body through the airways. CanSinoBIO is jointly developing the inhalation vaccine with the Beijing Institute of Biotechnology. To be clear, the company’s Adenovirus Type 5 Vector vaccine — or Ad5-nCoV — administered by injection was already approved for use in China and several other countries.  CanSinoBIO’s single-dose injected Covid vaccine has been approved for use in several countries including China, Pakistan, Mexico and Hungary.The company said interim data from phase three clinical trials overseas showed its vaccine was 68.83% effective at preventing symptomatic Covid-19 disease two weeks after one injection, while the rate fell to 65.28% after four weeks, reported Reuters.In comparison, updated data showed the Pfizer-BioNTech shot was 91% effective at preventing infection, while Moderna said its vaccine was more than 90% effective six months after the second shot.Yu said CanSinoBIO has studied adding a booster shot six months after the first injection, which managed to improve the immune response to the coronavirus. 

Reuters reported on Monday that Chinese researchers are testing mixing Covid vaccines developed by CanSinoBIO and a unit of Chongqing Zhifei Biological Products. The trial, under way in the eastern city of Nanjing, is expected to involve 120 participants, said the report.

China was the first country to report cases of Covid-19 in late 2019 and appears to have largely contained the outbreak. The country has said it aims to vaccinate 40% of its population by June.  

As big pharma races to save millions of lives there is a smaller less known “sleeping giant” in the CAR-T space developing advanced S-layer technology with limitless applications in the key development of an intranasal vaccine.  S-Layer  “surface layer” technology is used to develop an intranasal vaccine that attaches to the mucosal membrane CEO Dr. David Jin pointed out. “We see our vaccine candidate as a complement to any injectable vaccines in clinical trials, because it could provide first-line immune protection at the virus’s entrance site”. Adding a coat of an S-layer onto solid surfaces can greatly improve the function of a therapeutic, vaccine, or device. The S-layer allows enhanced efficiency and interaction of targeted proteins and molecules for better function.

 Avalon GloboCare is in the process of establishing a state-of-the-art research facility, the Christian Doppler Laboratory, located on the BOKU campus in Vienna, Austria, under the scientific leadership of Professor Eva-Kathrin Ehmoser, the Head of BOKU’s Institute for Synthetic Bioarchitectures and Professor Uwe Sleytr, a member of the Austrian Academy of Sciences. In connection with the new facility, Avalon and BOKU have signed a Memorandum of Understanding (MOU) to jointly apply for a matching research grant from the prestigious Christian Doppler Laboratory Foundation. Avalon also has research being done in MIT (Massachusetts Institute of Technology), the UNRLS (University of Natural Resources and life sciences in Australia), Weill Cornell Medicine in New York City and the Lu Daopei Medical Group in China, which has the country’s top ranked hematology and bone marrow transplant program 

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In the December 2020 issue of Nature’s Biopharma Dealmakers, Avalon’s President and CEO, David Jin, M.D., Ph.D., highlighted Avalon’s ongoing scientific and clinical developments including a first-in-human trial of a mucosal, intranasal vaccine against SARS-CoV-2 that is planned for early 2021. Dr. Jin also described the company’s innovative, allogeneic mesenchymal stromal cell (MSC) therapy candidate, CB-MSC-1, which possess unique anti-inflammatory and immunomodulatory activities, as well as AVA-001, Avalon’s third-generation CAR T cell therapy that has shown robust activity in patients with relapsed, refractory B cell acute lymphoblastic leukemia in a Phase 1 trial (Avalon feature in Biopharma Dealmakers).

“We are excited and motivated to join forces with the researchers at BOKU to drive innovation. We have already begun a collaboration on the mucosal SARS-CoV-2 vaccine and are moving quickly to establish additional joint research endeavors to bring about innovative technologies and new medicines to patients,” said Dr. Jin.

Avalon GloboCare, is a young, $100 million market cap company that has arguably some of the brightest minds in cell-based technology who have a competitive advantage with their “S-Layer” technology in a vaccine market that is expected to grow to approximately 93.billion by 2026 according to Forbes business . This small cap biotechnology company is working towards the goal of changing the way we fight the devastating effects of diseases that relentlessly attack our immune systems by using our own bodies against us. In the first quarter of 2020, Avalon GloboCare successfully completed a phase 1 first-in-human clinical study of AVA-001 in China for the treatment of relapsed refractory B cell acute lymphoblastic leukemia (R/R B-ALL). 90% of R/R B-ALL patients achieved complete remission with one dose and within one month of treatment, and then proceeded to a curative-intent allogeneic bone marrow transplant.  With more upcoming catalysts in early 2021, it is safe to say that there is a large potential upside in AVCO’s stock is currently trading at its 52 week know at 1.00 in change , as the market is anticipating updates on their progress on multiple clinical trials, leaving the question most investors are asking themselves.” When will Avalon GloboCare (NASDAQ:AVCO) take off ?” 

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